张良伟，博士，副研究员，硕士生导师。2013年6月，兰州大学获博士学位。2013年7月-2018年6月，兰州大学化学化工学院工作。2018年6月，加入中国科学院烟台海岸带研究所。主要研究方向是利用荧光成像分析技术研究典型污染物及其影响下内源性生物活性分子的生理和毒理效应，包括环境污染物监测、功能荧光染料开发、基于荧光成像技术发展环境污染物及内源性生物分子的动态监测工具、探究环境因素与疾病关系。目前，主持国家自然科学基金2项，参与4项。参与山东省重点研发计划2项。授权中国发明专利6件，参编专著1部。2019年入选中国科学院青年创新促进会会员。在J. Am. Chem. Soc., Chem. Sci., Chem. Commun., Anal. Chem.等期刊发表论文40余篇。已培养、协助指导10余名博士、硕士研究生，其中2人分别获中国科学院院长特别奖、中国科学院院长奖。Journal of Analysis and Testing青年编委。

近期主持科研项目：

1. 中国科学院青年创新促进会项目，环境胁迫荧光成像分析，2019-2022。

2. 国家自然科学基金，活细胞内特异性检测与标记蛋白亚磺酸的分子荧光探针构筑及成像研究，2018-2021。

3. 国家自然科学基金，检测活细胞内蛋氨酸亚砜还原酶活性的小分子荧光探针的构筑及生物应用，2015-2017。

代表性论文：

1. Li Zhang, Liangwei Zhang*, Xia Zhang, Ping Liu, Xiaoyue Han, Lingxin Chen*. Fluorescent imaging to provide visualized evidences for mercury induced hypoxia stress, Journal of Hazardous Materials, 2023, 444, Number. 1303074.

2. Shudi Liu^$*, Xia Zhang^$, Chaoxian Yan, Panpan Zhou, Li Zhang, Qingzhong Li, Renjie Zhang, Lingxin Chen*, Liangwei Zhang*. A small molecule fluorescent probe for mercury ion analysis in broad low pH range: spectral, optical mechanism and application studies, Journal of Hazardous Materials, 2022, 424, Number. 127701.

3. Xia Zhang, Li Zhang, Shudi Liu, Xiaozhen Zhu, Xinyan Cheng, Renjie Zhang, Liangwei Zhang*, Lingxin Chen*. Insight into sulfur dioxide and its derivatives metabolism in living system with visualized evidences via ultra-sensitive fluorescent probe, Journal of Hazardous Materials, 2022, 423, Number. 127179.

4. Yang Yang, Liangwei Zhang,* Xia Zhang, Shudi Liu, Yue Wang, Li Zhang, Huiyan You,* Zuo Ma and Lingxin Chen*. A cysteine-selective fluorescent probe for monitoring stress response cysteine fluctuations, Chemical Communications, 2021, 57(47), 5810-5813.

5. Yue Wang, Li Zhang, Xiaoyue Han, Liangwei Zhang*, Xiaoyan Wang, Lingxin Chen*, Fluorescent probe for mercury ion imaging analysis: strategies and applications, Chemical Engineering Journal, 2021, 406, Number. 127166.

6. Liangwei Zhang,* Jie Kang, Shudi Liu,* Xia Zhang, Jinyu Sun, Yuesong Hu, Yang Yang,and Lingxin Chen*. A chemical covalent tactic for bio-thiol sensing and protein labeling agent design, Chemical Communications, 2020, 56(77), 11485-11488.

7. Xia Zhang, Yan Huang, Xiaoyue Han, Yue Wang, Liangwei Zhang*, and Lingxin Chen*, Evaluating the protective effects of mitochondrial glutathione on cerebral ischemia/reperfusion injury via near-infrared fluorescence imaging, Analytical Chemistry, 2019, 91, 22, 14728-14736.

8. Liangwei Zhang*, Shoujiao Peng, Jinyu Sun, Ruijuan Liu, Shudi Liu, Jianguo Fang*, A ratiometric fluorescent probe of methionine sulfoxide reductase with improved response rate and emission wavelength, Chemical Communications, 2019, 55, 10, 1502-1505.

9. Liangwei Zhang, Shoujiao Peng, Jinyu Sun, Juan Yao, Jie Kang, Yuesong Hu and Jianguo Fang^*, A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease. Chemical Science, 2017, 8, 2966-2972.

10. Liangwei Zhang, Dongzhu Duan, Yaping Liu, Chunpo Ge, Xuemei Cui, Jinyu Sun, and Jianguo Fang*, Highly Selective Off？On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells. Journal of the American Chemical Society, 2014, 136, 226–233.

招生方向：

环境污染物监测技术，功能荧光染料、环境污染物及内源性生物分子动态监测工具的开发及应用、环境毒理与健康、诊断与治疗。

招生专业：海洋化学、环境工程

欢迎具有化学、海洋化学、材料科学、环境化学、生物化学、药物化学、分子生物学、细胞生物学等相关专业背景的同学报考。

联系方式：0535-2109133；Email：liangweizhang@yic.ac.cn